HIGH CORRELATION BETWEEN MOLECULAR ALTERATIONS OF THE C-MYC ONCOGENE AND CARCINOMA OF THE UTERINE CERVIX
- 1 August 1987
- journal article
- research article
- Vol. 47 (15) , 4173-4177
Abstract
We have examined 35 human tumors of the uterine cervix (carcinoma presenting the highest incidence in Mexico; about 34% of women''s malignant tumors) for alterations of the cellular myc (c-myc) protooncogene. Elevated amplification and/or rearrangement of the c-myc oncogene were detected in most (approximately 90%) samples (48% showed amplification and 43% presented both alterations). Most tumors were Stage II cervical carcinomas and for some of them we detected up to 60-fold amplification of c-myc. These results suggest an important role for c-myc oncogene in the development of tumors of the uterine cervix.This publication has 7 references indexed in Scilit:
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