Autoimmune Murine Thyroiditis
Open Access
- 1 March 1974
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 112 (3) , 965-969
- https://doi.org/10.4049/jimmunol.112.3.965
Abstract
The immune response to mouse thyroglobulin in mice is associated with the centromeric (left) side of the H-2 region. Thyroid infiltration is strongly controlled by a major gene, probably located between the K-end and the Ir-1 region, but other genes at the D-end of H-2, or outside of the H-2 region, may modify the response. Antibody formation is less strongly influenced by this major gene and may involve additional genetic or non-genetic factors.Keywords
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