Immunosuppressive Properties of Corticosteroids

Publisher Website
Google Scholar
Abstract
Aldosterone as well as its antagonist spirolactone prolong the survival time of allogeneic skin grafts from 10 to 14 days. The effect of a xenogeneic rabbit-anti-rat-lymphocyte serum is intensified by aldosterone; rats treated with ALS + aldosterone retained the allogeneic graft 5 days longer than those treated with ALS only. After large amounts of prednisolone the graft prolongation exceeded that of the aldosterone or spirolactone treated animals; the same is true for the combination with ALS. Prednisolone in a dose equivalent to the glucocorticoidal amount of the chosen aldosterone dose has no significant graft prolonging effect compared with the controls. Thus the graft-maintaining effect of aldosterone is believed to be independent of the glucocorticoidal component of this corticosteroid. The stimulation of endogenous aldosterone production is supposed to be responsible for the graft-prolonging effect of the aldosterone antagonist spirolactone. Clinical trials with aldosterone and spirolactone appear permissible in immunosuppressive therapy.

This publication has 0 references indexed in Scilit: