Etomidate and Plasma Esterase Activity in Man and Experimental Animals
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 18 (6) , 294-298
- https://doi.org/10.1159/000137268
Abstract
No hydrolysis of etomidate in plasma in vitro was detected in samples from man, horse, cow, sheep, guinea pig or white rabbit. Brown rabbits showed a moderate degree of hydrolysis and it was marked in plasma from Wistar rats. In this species, a single enzyme, an aliesterase, participated in the hydrolysis in plasma. Etomidate did not interfere with the hydrolysis of procaine by plasma pseudocholinesterase in man.Keywords
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