Inhibitory Effects of 1-Deazaadenosine Analogues on HIV Replication and Adenosine Deaminase

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 603-606
https://doi.org/10.1080/15257779508012435

Abstract

A series of 2′,3′-dideoxy-N⁶-(cyclo)alkyl-1-deazaadenosine derivatives were synthesized starting from 2,6-dichloro-1-deazapurine (9). The new nucleosides proved to be good inhibitors of HIV-1 replication, the most active being the 2′,3′-dideoxy-2-chloro-N⁶-cycloctyl-1-deazaadenosine (14h, ED₅₀ = 0.4 μ).

Keywords

DEAZAADENOSINE ANALOGUES
INHIBITORY
HIV
NUCLEOSIDES
GOOD
DEAMINASE
DEAZAPURINE
DICHLORO

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