METABOLISM OF EXOGENOUS SINGLE STRANDED DNA IN NORMAL AND NZB-W MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 32  (3) , 351-358
Abstract
Metabolism of ss[single-stranded]-DNA in Swiss Webster mice and NZB/W mice was studied. The delay in intra-hepatic catabolism of ssDNA in old NZB/W female mice seems to correlate with the presence of increased anti-DNA antibodies; this being similar to effects produced in Swiss Webster mice that were pretreated with a small dose of carbon black. Neither impairment in the phagocytic ability nor a decrease in DNase activity are found in the mice who are relatively unable to metabolize ssDNA. These observations are discussed in relation to possible [autoimmune lupus syndrome] pathogenesis in NZB/W mice.