ANTI-TUMOR EFFECT OF 1,1'-POLYMETHYLENE-BIS(1-NITROSOUREA) AND RELATED COMPOUNDS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 68  (5) , 573-580
Abstract
Three types of polymethylene-bis(1-nitroso) compounds were tested for antitumor effects against AH-13 rat hepatoma and L-1210 mouse leukemia. The bisnitrosoureas were effective against AH-13 and L-1210, bisnitrosoguanidines were effective against AH-13 alone, and bisnitrosotoluenesulfonamides were ineffective. Of all compounds, 1,1''-ethylene-bis(1-nitrosourea) (EBNU) was the most effective.

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