THE TWELFTH CHROMOSOME OF SACCHAROMYCES

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Abstract
The 12th chromosome of Saccharomyces was discovered by the genetical analysis of tetrad data from this and other laboratories. This newly established chromosme was identified by 2 tightly linked centromere markers, ly-7 (lysine requiring) and thr-5 (threonine requiring). Both markers have been located on the same arm of this chromosome in the gene order - centromere- thr-5 - ly-7. The map distance determined from the centromere to thr-5 was 31 stranes, from thr-5 to ly-7 was 11 (or 10) stranes, and from the centromere to ly-7 was 42 stranes. Both chromosomal and chromatid interference were absent in the region from the centromere to ly-7. In several crosses there were indications that this chromosome had undergone non-random assortment with chromosome VII.