Colloid-induced changes in bleeding following liver resection in the rat

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Abstract
The effect of preoperative infusion of Ringer's solution, Ringer's acetate solution, dextran 70, dextran 40, degraded gelatin and hydroxyethyl starch on haemostasis after standardized liver resection was studied in the rat. Ringer's and Ringer's acetate solutions did not affect haemostasis more than expected from haemodilution. Dextrans, degraded gelatin and hydroxyethyl starch caused a significant increase in bleeding time and blood loss. APT time was significantly increased after infusion of hydroxyethyl starch. Dextran and hydroxyethyl starch impaired ADP- and collagen-induced aggregation. Platelet aggregation was not affected by the infusion of Ringer's solution or Ringer's acetate solution as compared to non-treated controls.