Report of Joint Committee for Stroke Resources. IV. Brain edema in stroke.

Abstract
A classification of brain edema is provided and an extensive review of the animal models (squirrel monkey, gerbil, dog, cat, rhesus monkey, baboon, rat) from which most of the basic information about the formation and resolution of edema was derived. The clinical aspects of cerebral edema in stroke and modern methods for identifying cerebral edema in the human are discussed. Attention is given to computed tomography [CT] and enhanced CT, and advances in their application to this condition. Treatment of cerebral edema in the stroke patient using glycerol, dextran 40, mannitol, steroids and other drugs is discussed, and the need is pointed out for controlled clinical trials of the therapeutic effectiveness of these agents.