Influence of Manganese Intake on Metabolism of Manganese and Other Minerals in Sheep

Publisher Website
Google Scholar
Abstract
SIXTEEN wether lambs were used in a 2×2 factorial arrangement of treatments to study the metabolism of manganese. One hundred microcuries of 54Mn as MnCl2, were administered either orally or intravenously to lambs fed a basal (30 ppm manganese), or basal diet plus 4,000 ppm supplemental manganese. A 21-day fecal and urinary collection period followed the dosing with radioactive manganese. After an additional 35 days, the lambs were dosed again in a similar manner with 54Mn. Following this dosing, blood samples were taken at intervals for 96 hr., after which all animals were killed and tissues removed for analysis. Absorption of 54Mn was low and excretion of both stable manganese and 54Mn was almost exclusively by way of the feces regardless of dietary manganese level or pathway of isotope administration. Low dietary manganese and intravenous administration of 54Mn resulted in the greatest tissue retention of radioactivity. Lambs receiving low dietary manganese retained more 54Mn in tissues than did lambs fed supplemental manganese. Tissue and plasma levels of stable manganese were higher in lambs fed the manganese-supplemented diet. High dietary manganese resulted in decreased concentrations of tissue iron and zinc. Copyright © 1973. American Society of Animal Science . Copyright 1973 by American Society of Animal Science.