Sodium Channel Inactivation in Squid Axon Is Removed by High Internal p H or Tyrosine-Specific Reagents
- 30 June 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4349) , 1494-1496
- https://doi.org/10.1126/science.26973
Abstract
In squid axon, internal alkalinization from pH 7.1 to pH 10.2 results in a reversible decrease of the maximum inward current and the steady state sodium channel inactivation. Similar effects were observed after treatment of the axon with tetranitromethane or after iodination with lactoperoxidase. These results suggest that a tyrosine residue is an essential component of the inactivation process in this nerve.This publication has 11 references indexed in Scilit:
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