The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

This publication has 27 references indexed in Scilit:

• Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus
  Annual Review of Physiology, 1985
• The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling
  Cell, 1985
• Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
  Nature, 1985
• Insulin-induced Loss of Insulin-like Growth Factor-I Receptors on IM-9 Lymphocytes
  Diabetes, 1982
• Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
  Science, 1982
• Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors
  Biochemistry, 1981
• Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose
  Immunochemistry, 1978
• [16] Methods for assessing immunologic and biologic properties of iodinated peptide hormones
  Published by Elsevier ,1975
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
  Nature, 1970
• IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MAN
  Journal of Clinical Investigation, 1960