First report of chronic meningitis caused byTrichosporon beigelii

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Abstract
Trichosporon beigelii (Trichosporon cutaneum) was identified as the causative agent of chronic meningitis in a 15-year-old boy with acute lymphocytic leukaemia. After a neutropenic episode following cytostatic treatment and itraconazole therapy as prophylaxis, cerebrospinal fluid (CSF) samples yielded growth ofTrichosporon beigelii. Treatment with amphotericin B, flucytosine and high doses of fluconazole was followed by clinical improvement, although CSF pleocytosis remained. The cross-reactivity betweenCryptococcus neoformans andTrichosporon beigelii in a cryptococcal antigen latex test was used as a means of diagnosis in CSF and serum samples.

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