Hormone-Replacement Therapy and Heart Disease

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Abstract
To the Editor: The correspondence (July 10 issue) on the contradictory results of the two studies1 , 2 published in the Journal on estrogen-replacement therapy and cardiovascular disease (including myocardial infarction) appears, at first reading, to leave the issue unresolved.3 The majority of epidemiologic studies of this very important issue describe a substantial reduction in the risk of cardiovascular disease among users of estrogen-replacement therapy.4 The report from the Framingham study,1 with apparently completely contrary results, provides the main evidence against such a protective effect. In the recent correspondence, however, Wilson and his colleagues5 have kindly given sufficient details of their results . . .