Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 44 (1) , 38-40
- https://doi.org/10.1007/bf01960237
Abstract
Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient diet developed a higher incidence of diabetes and more severe hyperglycemia than those on the control diet.This publication has 18 references indexed in Scilit:
- Mechanisms of Nitrosourea-Induced β-Cell Damage: Alterations in DNADiabetes, 1986
- Chemically and Hormonally Induced Diabetes MellitusPublished by Springer Nature ,1985
- Molecular basis of experimental diabetes: Degeneration, oncogenesis and regeneration of pancreatic B‐cells of islets of LangerhansBioEssays, 1985
- Effects of streptozotocin on a clonal isolate of rat insulinoma cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984
- Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic isletsNature, 1981
- Streptozotocin Diabetes CORRELATION WITH EXTENT OF DEPRESSION OF PANCREATIC ISLET NICOTINAMIDE ADENINE DINUCLEOTIDEJournal of Clinical Investigation, 1974
- Streptozotocin diabetes—further studies on the mechanism of depression of nicotinamide adenine dinucleotide concentrations in mouse pancreatic islets and liverBiochemical Pharmacology, 1973
- Significance of streptozotocin induced nicotinamide‐adenine‐dinucleotide (NAD) degradation in mouse pancreatic isletsFEBS Letters, 1973
- Streptozotocin Diabetes: Time Course of Irreversible B-Cell Damage; Further Observations on Prevention by NicotinamideExperimental Biology and Medicine, 1970
- Reversal of Streptozotocin Diabetes with NicotinamideExperimental Biology and Medicine, 1969