Ehlers–Danlos Syndrome

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Abstract
The first comprehensive description of a syndrome comprising laxity and fragility of the skin associated with hypermobility of the large joints was published in 1892 by Tschernogobow1 in Moscow. With remarkable insight, he interpreted the cause of the phenotype as a systemic defect in connective tissue. However, as is common in medicine, those who came later are immortalized in the eponym, in this case Ehlers2 and Danlos,3 Danish and French dermatologists, respectively, who published their observations independently in the first decade of the 20th century.The familial nature of these clinical associations was demonstrated in 1949,4 and soon thereafter Jansen . . .