AN ANSWER TO THE SPIRO VS ANSA DILEMMA IN CYCLOPHOSPHAZENES. PART VIII. THE FIRST FUSED DISPIROCYCLOTRIPHOSPHAZENES, N3P3CL2[HN[sbnd](CH2)m[sbnd]NH] [HN[sbnd](CH2)N[sbnd]NH](m ≠ n = 2,3,4)
- 13 December 1985
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 25 (3) , 273-287
- https://doi.org/10.1080/03086648508072743
Abstract
The synthesis of the first fused DISPIROcyclotriphosphazenes was achieved upon reaction of a diamine H2N[sbnd](CH2)m[sbnd]NH2 (with m = 2,3,4) on the N3P3Cl4[HN[sbnd](CH2) n [sbnd]NH2] (with n ≠ m) MONOSPIRO derivative in stoichiometric conditions. Molecular structures were ascribed by using both 31P and 1H high resolution NMR and electron-impact mass spectrometry. The chemical shift of the phosphorus atoms bearing the loop varies linearly with the value of the corresponding NPN endocyclic angle. The synthesis of this fused derivatives occurs in quantitative yield. It leads the way for the covalent binding at demand on a cyclophosphazene antitumoral system of several natural polyamines as tumor finders in the SPIRO configuration.Keywords
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