Induction of Increased Benzpyrene Hydroxylase Activity in Pulmonary Tissue in Vitro

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Abstract
A technique has been developed for obtaining induction of increased benzpyrene hydroxylase activity in short-term cultures of rat pulmonary tissue. Several pheno-thiazines, polycyclic hydrocarbons, and other compounds which induce increased benzpyrene hydroxylase activity in vivo when administered to rats will likewise induce an increased activity of this enzyme system in vitro when added to the culture system.