Brill's Disease

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Abstract
THE name Brill's disease is usually given to the isolated cases of typhus fever that occur in the coastal towns of the northeastern United States.1 In 1934 Zinsser2 showed that these cases develop almost exclusively in immigrants from areas where there have been epidemics of louse-borne typhus fever. He demonstrated that the rickettsias that he was able to isolate from a few of these patients resembled the causative agent of epidemic or louse-borne typhus fever but that the disease was not associated with louse infestation. He came to the conclusion that Brill's disease represented a recrudescence of a latent infection . . .

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