Comparison of the prothrombin—proconvertin determinations owren—aas with “prothrombin—index” obtained with the larsen—plum prothrombin time method

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Abstract
From 63 patients treated with Dicoumarol anticoagulants, 765 blood samples were examined by the prothrombin-proconvertin method of Owren-Aas and by the prothrombin time method of Larsen-Plum (with human non-dried brain thromboplastin). Indices were calculated on the basis of the latter method and plotted against the PP-values. The scattering of points representing indices is not necessarily due to errors inherent in the Larsen-Plum methods, but may reflect individual variations in coagulation factors which are kept constant in the Owren-Aas method. The 2 methods were used for daily examination through 10-15 days or more of patients treated with Dicoumarol-anticoagulants with and without vitamin K. Results show less variation of the "Index" than found by authors who have worked with acetone extracted dried rabbit brain.

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