Effect of Age on in Vivo Urinary Bladder Function in the Rat
- 29 February 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 139 (3) , 625-627
- https://doi.org/10.1016/s0022-5347(17)42546-8
Abstract
The effects of age on micturition in male Fischer 344 rats, ages five to seven, 16 to 18 and 22 to 24 months, were studied. The 24 hr. water intake, 24 hr. urine output, frequency and volume of each micturition were obtained from rats housed individually in metabolic cages. Intravesical pressure and volume at which the micturition contraction occurred were evaluated using natural-fill cystometry. The 24 hr. water intake and urine output increased significantly with advancing age; 22 to 24 month rats showed a 39% increase in water intake and a 93% increase in urine output compared to five to seven month rats. The increase in urine output observed in the 22 to 24 month old rats was manifested by a 95% increase in volume per micturition and a 52% increase in frequency of micturition compared to five to seven month old rats. The pressure at micturition (PAM) was 100% greater in 22 to 24 and 16 to 18 month old rats compared to five to seven month old rats with no age-related difference in bladder volume at micturition (BVM). These studies demonstrate that in vivo micturition changes with age in the male F344 rat. Although there were no overt urological dysfunctions observed in the aging rats, the alterations in function would indicate that there were changes in either the mechanisms controlling micturition, or changes in the musculature itself. These possibilities will be the subject of further investigations.This publication has 15 references indexed in Scilit:
- Effect of Exercise Training on Resting Blood Pressure and Heart Rate in Adult and Aged RatsJournal of Gerontology, 1987
- Age-related change in α-adrenergic responsiveness of the urinary bladder of the rat is regionally specificNeuropharmacology, 1986
- Effect of Age on Cholinergic Muscarinic Responsiveness and Receptors in the Rat Urinary BladderJournal of Urology, 1986
- Age-Related Reduction of Baroreflex Tachycardia Without Loss of β-Adrenoceptor–Mediated Tachycardia in Sprague–Dawley RatsJournal of Cardiovascular Pharmacology, 1986
- Effect of Age of Initiation of Feed Restriction on Growth, Body Composition, and Longevity of RatsJournal of Gerontology, 1986
- Electrophysiological Markers of Aging and Memory Loss in RatsaAnnals of the New York Academy of Sciences, 1985
- Effect of aging on pancreatic secretion in ratsThe American Journal of Surgery, 1985
- Age-related changes in sensitivity of rat urinary bladder to atonomic agentsMechanisms of Ageing and Development, 1984
- Urinary concentrating defect in the aged ratAmerican Journal of Physiology-Renal Physiology, 1981