Antigenic Competition in IgE, IgG1 and IgG2 Antibody Production in the Mouse

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Abstract
A comparative study of the effects of antigenic competition on the IgE, IgG1 and IgG2 antibody production was performed in mice immunized with two unrelated antigens. These antigens were injected as a mixture or in different sites. In addition, the groups of mice received one or three boosters of one or both antigens. The passive cutaneous anaphylaxis titres obtained in several bleedings showed a suppression of IgG1 and IgG2 antibody responses only in the groups injected with the two antigens in the same site, independently of antigenic boosters. The IgE antibody response was diminished when the antigens were given in a mixture, but this effect disappeared after a second booster. In contrast, groups injected with antigens separately started to show a suppressed response only at this time.

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