Updating the asymmetric osmium‐catalyzed dihydroxylation (AD) mnemonic: Q2MM modeling and new kinetic measurements
- 1 January 2003
- Vol. 15 (4) , 360-368
- https://doi.org/10.1002/chir.10214
Abstract
The mnemonic device for predicting stereoselectivities in the Sharp‐less asymmetric dihydroxylation (AD) reaction has been updated based on extensive computational studies. Kinetic measurements from competition reactions validate the new proposal. The interactions responsible for the high stereoselectivity in the title reaction are analyzed in detail and mapped onto the mnemonic device. Chirality 15:360–368, 2003.Keywords
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