Antiganglioside Antibodies in Multifocal Acquired Sensory and Motor Neuropathy

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Abstract
MULTIFOCAL acquired sensory and motor neuropathies are usually classified as demyelinating or axonal. The demyelinating neuropathy, also referred to as "multifocal motor and sensory demyelinating neuropathy," "multifocal acquired demyelinating sensory and motor neuropathy," or the "Lewis-Sumner syndrome," is thought to be a variant of chronic inflammatory demyelinating polyneuropathy, and to be immune mediated.1-4 In the absence of evidence for demyelination, the multifocal neuropathy is thought to be axonal, and may be associated with vasculitis, diabetes mellitus, sarcoid, and Lyme disease, among others. If no cause is found, however, the neuropathy is considered idiopathic.5