Transforming growth factor α and epidermal growth factor levels in normal human gastrointestinal mucosa
- 1 November 1989
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 60 (5) , 657-660
- https://doi.org/10.1038/bjc.1989.334
Abstract
Acid soluble proteins from 23 samples of normal human gastrointestinal mucosa derived from four normal adult organ donors were extracted and subjected to specific radioimmunoassays for transforming growth factor .alpha. (TGF.alpha.) and urogastrone epidermal growth factor (URO-EGF). All tissues were found to contain immunoreactive TGF.alpha. and levels ranged from 57 to 4,776 pg-1 wet weight of tissue. Although levels varied between tissue donors, the distribution of TGF.alpha. throughout the gastrointestinal tract appeared similar in all cases. URO-EGF levels were much lower (0-216 pg g-1 wet weight). TGF.alpha. levels in extracts of gastrointestinal mucosa from a 7-year-old female donor were higher and the observed distribution was markedly different from adult levels. URO-EGF was not detected in mucosal or submucosal tissue extracts from this patient. Further studies in juveniles are indicated.Keywords
This publication has 29 references indexed in Scilit:
- Faculty Opinions recommendation of Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.Published by H1 Connect ,2013
- Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor.Proceedings of the National Academy of Sciences, 1983
- Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.Journal of Clinical Investigation, 1983
- Hormonal Regulation of Epidermal Growth Factor and Protease in the Submandibular Gland of the Adult Mouse*Endocrinology, 1981
- Effect of Thyroxine, Testosterone, and Corticosterone on Nerve Growth Factor (NGF) and Epidermal Growth Factor (EGF) Concentrations in Adult Female Mouse Submaxillary Gland: Dissociation of NGF and EGF Responses*Endocrinology, 1981
- Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.Proceedings of the National Academy of Sciences, 1980
- The identification of urogastrone in serum, saliva, and gastric juiceGastroenterology, 1979
- Epidermal Growth Factor (Urogastrone) in Human Fluids: Size Heterogeneity*Journal of Clinical Endocrinology & Metabolism, 1979
- Cellular localisation of human urogastrone/epidermal growth factorNature, 1978
- The Effect of Progestins on Submaxillary Gland Epidermal Growth Factor: Demonstration of Androgenic, Synandrogenic and Antiandrogenic ActionsEndocrinology, 1975