IMMUNOTHERAPY OF AN ESTABLISHED RAT MAMMARY ADENOCARCINOMA (13762A) WITH INTRATUMOR INJECTION OF CORYNEBACTERIUM-PARVUM

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 689-692
Abstract
The effects of intratumor injection of C. parvum vaccine on the survival of 13762A tumor-bearing rats were studied. Vaccine injection of established (7-day-old) tumors produced dose-related prolongation of survival and cured some animals. Although 30-40% of the vaccine-injected primary tumors regressed, recurrences and continued growth of metastases killed 1/4 of the regressors. Rats given 1500 .mu.g of C. parvum intratumorally at 7 days, with or without later primary tumor excision at 20 days, were cured at a rate of 10-40%. Repeated injections improved the results (60%). C. parvum injections delayed until 12 and 17 days were ineffective. Cured rats were immune to re-challenge with 13762A tumor.

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