SULFHYDRYL GROUPS AND THE INTERACTION BETWEEN THE HEMES IN HEMOGLOBIN
Open Access
- 20 September 1952
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 36 (1) , 1-16
- https://doi.org/10.1085/jgp.36.1.1
Abstract
1. Dialysis of a hemoglobin solution against slightly alkaline buffer (pH 8.68) causes a decrease in heme-heme interaction. The value of n in Hill's equation drops from 2.9 to 2.0, while the oxygen affinity increases slightly. Addition of glutathione largely reverses the effects of dialysis (n rises from 2.0 to 2.5 to 2.6).Keywords
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