Identification of pediatric septic shock subclasses based on genome-wide expression profiling
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Open Access
- 22 July 2009
- journal article
- Published by Springer Nature in BMC Medicine
- Vol. 7 (1) , 34
- https://doi.org/10.1186/1741-7015-7-34
Abstract
Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies. Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through genome-wide expression profiling.Keywords
This publication has 42 references indexed in Scilit:
- Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum*Critical Care Medicine, 2009
- Distinct Hemodynamic Patterns of Septic Shock at Presentation to Pediatric Intensive CarePediatrics, 2008
- Interleukin-8 as a Stratification Tool for Interventional Trials Involving Pediatric Septic ShockAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Pediatric Septic Shock Treatment: New Clues from Genomic ProfilingPharmacogenomics, 2007
- Heterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shockCritical Care Medicine, 2006
- Application of genome-wide expression analysis to human health and diseaseProceedings of the National Academy of Sciences, 2005
- Measures, markers, and mediators: Toward a staging system for clinical sepsis. A Report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25–26, 2000Critical Care Medicine, 2003
- Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES StudyCritical Care Medicine, 2001
- Hemodynamic Support in Fluid-refractory Pediatric Septic ShockPediatrics, 1998
- Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shockCritical Care Medicine, 1996