TREATMENT OF MYCOSIS-FUNGOIDES BY PUVATHERAPY - REPORT ON 18 CASES

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 105  (3) , 291-298
Abstract
A group of 18 patients with mycosis fungoides was treated by PUVA therapy [8-methoxypsoralen long wave UV]. According to VanScott classification, there were 5 stage I, 6 stage II, 3 stage III, 2 stage IV, 1 Sezary syndrome and 1 erythroderma case. There was complete clearing of 12 patients (66%); 2 patients (11%) had improved cutaneous lesions without a complete clearing, and there was no response to treatment for 3 patients (22%) (1 with erythroderma, 1 with Sezary syndrome and 1 stage IV, and 1 abandoning therapy). Orally administered methoxalen [8-methoxypsoralen] was given according to body area (mg/m2) and some of the patients had twice daily PUVA therapy. PUVA therapy seemed the least dangerous and most effective treatment for the patients in the early stages of mycosis fungoides (I, II) and nitrogen mustard, electron therapy, corticoids and even mono- or polychemotherapy could be combined with PUVA therapy, if necessary, for the stages III and IV.

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