PHYSOSTIGMINE FOR MUSCLE SPASM IN RHEUMATOID ARTHRITIS
- 2 February 1946
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 130 (5) , 265-270
- https://doi.org/10.1001/jama.1946.02870050017004
Abstract
Following the work of Kabat and Knapp1 reporting the use of neostigmine in the treatment of muscle spasm in poliomyelitis, our attention was drawn to the problem of muscle spasm in rheumatoid arthritis and allied conditions. The incidence of rheumatoid arthritis is so great and the various forms of therapy so numerous that it should be our purpose to reduce the treatment of this disease to the simplest denominator. Any form of therapy that tends to minimize deformities should be considered worthy of consideration. Our object in this writing is to (1) prevent deformities in rheumatoid arthritis, (2) lessen the severity of deformities already formed, (3) simplify the drug used, (4) lessen the cost to the patient and (5) relieve pain. In April 1944 we published a preliminary report2 on the use of neostigmine in the treatment of muscle spasm in rheumatoid arthritis. The present report, while supplementary,Keywords
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