Effects of nicardipine on frog skeletal muscle in normal and calcium-free media.

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Abstract
The effects of the new "Ca-antagonist," nicardipine, on frog skeletal muscle were studied. Nicardipine (3 .times. 10-10-3 .times. 10-7 M) had no effect on twitch tension yet a high concentration (3 .times. 10-6 M) had a slight potentiating effect, with no effect on the action potential. Nicardipine suppressed the repetitive action potentials induced by perfusion of a Ca-free solution and thereby suppressed augmentation of the tension responses, in a dose dependent manner. A high concentration of nicardipine (3 .times. 10-6 M) abolished the twitch tension due to inhibition of the action potential, in Ca-free solution. These abolitions of the action potential and twitches induced by nicardipine in Ca-free solution were antagonized in the case of NaCl hypertonic solution. Therefore, nicardipine probably inhibits Na permeability in frog skeletal muscle placed in Ca-free solution.

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