TUMOR-CELL CYTOSTASIS BY MACROPHAGES AND ANTIBODY INVITRO .1. RESOLUTION INTO CONTACT-DEPENDENT AND CONTACT-INDEPENDENT STEPS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 120  (5) , 1560-1566
Abstract
In a murine system, macrophages, in concert with antibody, suppressed iododeoxyuridine incorporation by tumor cells [line 1 mouse lymphoblastoid cells]. The mechanism of suppression did not involve phagocytosis or lysis. The generation of suppressed tumor cells was resolved into a contact-dependent step and a contact-independent step. The 1st step was 1-hit with respect to macrophages and multi-hit with respect to antibody.