SUCCINYLCHOLINE CHLORIDE IN ELECTROSHOCK THERAPY

1 February 1954

journal article
other
Published by American Medical Association (AMA) in A.M.A. Archives of Neurology & Psychiatry

Vol. 71 (2) , 189-197
https://doi.org/10.1001/archneurpsyc.1954.02320380055007

Abstract

IN THE preceding paper, clinical data were presented concerning electroshock therapy in conjunction with administration of the muscle-relaxant drug succinylcholine chloride. Some of the other muscle-relaxant drugs have a definite effect directly on the autonomic system and thus indirectly on the circulation. Tubocurarine (d-tubocurarine) chloride is said to produce partial blockade of the autonomic system,¹while gallamine (Flaxedil) initiates a tachycardia through its inhibiting effect on the cardiac vagal fibers.²Tubocurarine chloride also produces a decrease in systemic blood pressure which is not prevented by atropine. This effect is thought to be partially related to its autonomic ganglion-blocking properties and partially to a histamine liberation.³The latter property is responsible for the bronchospasm which is occasionally seen in clinical anesthesia. Although succinylcholine is closely related chemically to the ganglion-blocking (hypotensive) methonium drugs and to acetylcholine, previous workers⁴have been unable to show any adverse effect on

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