Methyl 4-Hydroxy-3-(3‘-methyl-2‘-butenyl)benzoate, Major Insecticidal Principle from Piper guanacastensis
- 1 March 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (3) , 282-284
- https://doi.org/10.1021/np960601x
Abstract
The CHCl3-soluble extract of Piper guanacastensis (Piperaceae) was found to have noteworthy insecticidal activity to Aedes atropalpus mosquito larvae (LC50 80.5 micrograms/mL). Bioassay-guided fractionation afforded methyl 4-hydroxy-3-(3'-methyl-2'-butenyl)benzoate (1) as the major bioactive constituent (LC50 20.5 micrograms/mL). The separation of compound 1 from its transesterification artifact (2), ethyl 4-hydroxy-3-(3'-methyl-2'-butenyl)benzoate, was achieved by recycling reversed-phase HPLC. The flavonoids acacetin, chrysin, and pinostrobin were also isolated from the active fraction but did not display insecticidal properties.Keywords
This publication has 6 references indexed in Scilit:
- Insecticidal Neolignans from Piper decurrensJournal of Natural Products, 1996
- Insecticidal defenses of Piperaceae from the neotropicsJournal of Chemical Ecology, 1995
- Two chromenes and a prenylated benzoic acid derivative from Piper aduncumPhytochemistry, 1993
- Toxins Produced by the Dogwood Anthracnose Fungus Discula sp.Journal of Natural Products, 1991
- Flavonoids from Salvia nicolsonianaJournal of Natural Products, 1986
- Estimating LD50Using the Probit Technique: A Basic Computer ProgramDrug and Chemical Toxicology, 1983