Ecto-5′-Nucleotidase Activity in T and B Lymphocytes from Normal Subjects and Patients with Congenital X-Linked Agammaglobulinemia

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Abstract
Ecto-5′-nucleotidase activity was measured in lymphocyte subpopulations isolated from normal subjects and patients with congenital X-linked agammaglobulinemia. B lymphocytes from normal subjects have at least three times more ecto-5′-nucleotidase activity than T lymphocytes. Patients with X-linked agammaglobulinemia have 56% of normal activity in their T cells, and lack a lymphocyte subpopulation high in nucleotidase activity. High activity of ecto-5′-nucleotidase may be a biochemical marker for mature surface immunoglobulin-bearing B cells.