HISTAMINASE IN THE TREATMENT OF ALLERGY

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Abstract
The theory that the liberation of histamine in the tissues is the immediate cause of the signs and symptoms of allergy has led to the use of its antagonist, the enzyme histaminase, for the prevention and alleviation of these phenomena. Elsewhere we1have discussed in more detail the theoretical considerations pro and con of this use of histaminase. Here we shall concern ourselves only with the report of the results of the clinical trial of histaminase as a therapeutic and prophylactic drug. For a fairly complete review of the clinical experience of others, we refer to Laymon and Cumming's2recent publication of their presentation before the Society for Investigative Dermatology. This, together with the accompanying discussions of the other members of the society, leaves the impression that the clinical value of the use of histaminase is highly questionable. In view of this conclusion, our only reason for presenting

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