Although research on late-life depression is burgeoning, little attention has been given to the sampling and recruitment obstacles encountered in trying to enlist the participation of older adults in such studies. In this article, the authors summarize the response rates of 15 recent epidemiological studies and 100 descriptive studies examining late-life depression among community-dwelling older adults. These studies excluded approximately 25-35% of potential participants. The authors present evidence suggesting that because depressed older adults may be especially likely to refuse research invitations, researchers may overlook or underestimate important correlates of depression. In addition, the authors describe several strategies for enhancing recruitment efforts.