Effect of R‐plasmid RP1 and Nutrient Depletion on the Resistance of Escherichia coli to Cetrimide, Chlorhexidine and Phenol

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Abstract
The minimum inhibitory concentation of cetrimide and chlorhexidine for Escherichia coli is altered when R‐plasmid RPI is inserted into it. Using disinfectant‐agar plates as a test system, the sensitivity of Esch. coli to these disinfectants and to phenol was found to vary, not only with the presence of RPI, but also with the nutritional status of the inoculum. The different inocula also varied in their ability to bind H+ and there was some correlation between this property and chlorhexidine sensitivity.