COMPARATIVE EFFECTS OF VARIOUS ANTIMETABOLITES ON GROWTH AND SYNTHESIS OF CITROVORUM FACTOR BY STREPTOCOCCUS FAECALIS

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Abstract
A representative group of antimetabolites were tested for their effects on synthesis of citrovorum factor (CF) by washed-cell suspensions of S. faecalis ATCC No. 8043. The following compounds were as effective in inhibiting CF synthesis from folic acid as in inhibiting the growth of this bacterium: 2,4-diamino-10-methyl pteroyl glutamic acid (amethopterin); 2,4-diamino-5-p-chlorophenyl-6-ethyl pyrimidine (pyrimethamine); 2,4-diamino-6-chloroquinazoline; 2,4-diamino-6,7-dimethyl pteridine; and 2,4-diaminoquinazoline.On the other hand, much higher concentrations of 2,4-diamino-5,6-dimethyl pyrimidine and 2,6-diaminopurine were required to inhibit CF synthesis than growth of S. faecalis. This may be due to an additional effect of these compounds on purine and pyrimidine metabolism in growth cells.

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