How do eukaryotic activator proteins stimulate the rate of transcription by RNA polymerase II?
- 27 July 1992
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 307 (1) , 81-86
- https://doi.org/10.1016/0014-5793(92)80906-w
Abstract
A large number of activator proteins have now been identified in higher and lower eukaryotes, which bind to the regulatory regions or protein‐encoding genes and increase the rate at which they are transcribed by RNA polymerase II. The mechanism by which activators function is being intensively studied and some of the targets of transcriptional activation domains have now been identified. These studies have also revealed novel classes of regulatory factors, which were not anticipated by extrapolating from the principles obtained with prokaryotic promoters.Keywords
This publication has 57 references indexed in Scilit:
- The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivoCell, 1992
- Isolation of Two Genes That Encode Subunits of the Yeast Transcription Factor IIAScience, 1992
- Chromatin as an essential part of the transcriptional mechanimNature, 1992
- The complexities of eukaryotic transcription initiation: regulation of preinitiation complex assemblyTrends in Biochemical Sciences, 1991
- Sequence of general transcription factor TFIIB and relationships to other initiation factors.Proceedings of the National Academy of Sciences, 1991
- Cloning of a human gene encoding the general transcription initiation factor IIBNature, 1991
- RNA POLYMERASE B (II) AND GENERAL TRANSCRIPTION FACTORSAnnual Review of Biochemistry, 1990
- The “initiator” as a transcription control elementCell, 1989
- Gene regulation by proteins acting nearby and at a distanceNature, 1986
- Organization and Expression of Eucaryotic Split Genes Coding for ProteinsAnnual Review of Biochemistry, 1981