Nucleophilic Displacement Reactions on Sterically Hindered Chloro‐Pyridines: Some Optimisation Studies
- 1 January 1992
- journal article
- european section
- Published by Wiley in Bulletin des Sociétés Chimiques Belges
- Vol. 101 (4) , 297-302
- https://doi.org/10.1002/bscb.19921010409
Abstract
A Factorial Design has been used to optimise the reaction conditions for the nucleophilic displacement of chlorine in 2‐chloro‐4,6‐diisopropyl‐5‐nitropyridine (1B) by 4‐chlorophenol. The results obtained have been successfully applied to a large variety of phenols and thiophenol.Keywords
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