The effects of heterologous sera on the uptake of rabbit antibody from the gut of young mice

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Abstract
The severity of haemolytic anaemia in young mice injected or fed with an anti-mouse haemolytic antiserum prepared in rabbits depends on the dose administered. The dosemortality relationship for injecting the antiserum alone, and the concentration-mortality relationships for feeding the antiserum diluted with other non-immune sera to young mice were determined. The amounts of rabbit antibody which could reach the circulation from the gut was estimated from these. The presence of other non-immune sera in doses of the anti-serum had the effect of reducing the amount of rabbit antibody which reached the circulation, but to an extent that could not be accounted for by dilution. The extent of this effect depended on the specificity of the non-immune sera and on their proportion in the ingested mixtures of sera.

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