Controversy in Basic Sciences Is TNF Really Involved in Cachexia?
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Cancer Investigation
- Vol. 15 (1) , 47-54
- https://doi.org/10.3109/07357909709018916
Abstract
A review on the possible involvement of tumor necrosis factor-alpha (TNF) in cachexia is presented. While this cytokine is definitely linked to sepsis and tumor-associated weight loss in some experimental models, other cytokines, such as interleukin-6 (IL-6) or interferon-gamma (IFN-gamma), alone or in combination with TNF, may also play an important role in the development of cachexia.Keywords
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