Retinol‐binding protein‐4 attenuates insulin‐induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes
Open Access
- 15 June 2007
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 21 (13) , 3696-3704
- https://doi.org/10.1096/fj.07-8173com
Abstract
Reduced sensitivity to insulin in adipose, muscle, and liver tissues is a hallmark of type 2 diabetes. Animal models and patients with type 2 diabetes exhibit elevated levels of circulating retinol-b...Keywords
This publication has 25 references indexed in Scilit:
- Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytesBiochemical and Biophysical Research Communications, 2006
- Attenuation of Insulin-stimulated Insulin Receptor Substrate-1 Serine 307 Phosphorylation in Insulin Resistance of Type 2 DiabetesJournal of Biological Chemistry, 2005
- Restraining PI3K: mTOR signalling goes back to the membraneTrends in Biochemical Sciences, 2005
- Positive and negative regulation of insulin signaling through IRS-1 phosphorylationBiochimie, 2005
- Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetesThe FEBS Journal, 2004
- Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistanceBiochemical Society Transactions, 2004
- Expression of a mutant IRS inhibits metabolic and mitogenic signalling of insulin in human adipocytesMolecular and Cellular Endocrinology, 2004
- Modulation of insulin actionDiabetologia, 2004
- Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 DiabetesDiabetes, 2003
- Insulin signalling and the regulation of glucose and lipid metabolismNature, 2001