The Cyclin-dependent Kinase Inhibitor p21CIP/WAF Is a Positive Regulator of Insulin-like Growth Factor I-induced Cell Proliferation in MCF-7 Human Breast Cancer Cells
Open Access
- 1 September 2003
- journal article
- Published by Elsevier
- Vol. 278 (39) , 37256-37264
- https://doi.org/10.1074/jbc.m302355200
Abstract
No abstract availableKeywords
This publication has 47 references indexed in Scilit:
- The Cyclin-dependent Kinase Inhibitor p21WAF1/Cip1 Is an Antiestrogen-regulated Inhibitor of Cdk4 in Human Breast Cancer CellsPublished by Elsevier ,2002
- Multifaceted Regulation of Cell Cycle Progression by Estrogen: Regulation of Cdk Inhibitors and Cdc25A Independent of Cyclin D1-Cdk4 FunctionMolecular and Cellular Biology, 2001
- Inhibitory effect of p21 in MCF-7 cells is overcome by its coordinated stabilization with D-type cyclinsOncogene, 1999
- FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cellsOncogene, 1998
- Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer CellsPublished by Elsevier ,1998
- Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein KinaseJournal of Biological Chemistry, 1997
- Dephosphorylation of Cdk2 Thr 160 by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of CyclinScience, 1995
- Two variants of the CIP1/WAF1 gene occur together and are associated with human cancerHuman Molecular Genetics, 1995
- p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Published by Elsevier ,1994
- p21 is a universal inhibitor of cyclin kinasesNature, 1993