Interindividual variability in the enantiomeric disposition of ibuprofen following the oral administration of the racemic drug to healthy volunteers

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Abstract
The plasma disposition of the enantiomers of ibuprofen has been investigated following the oral administration of the racemic drug (400 mg) to 24 healthy male volunteers. The plasma elimination of (R)‐ibuprofen was found to be more rapid than that of the S‐enantiomer [plasma half‐life: (R) 2.03 h; (S) 3.05 h; 2P < 0.001], resulting in a progressive enrichment in the plasma content of this isomer, some 64% of the total area under the plasma concentration time curves (AUC) being due to the pharmacologically active enantiomer. The influence of dose on the pharmacokinetic characteristics of the enantiomers of ibuprofen, over the range 200–800 mg, was investigated in three subjects. Examination of dosenormalized AUC values and oral clearance indicate the dose dependence of (R)‐ibuprofen disposition.