Absence of an Association Between Past Infection with Hepatitis A Virus and Primary Hepatocellular Carcinoma

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Abstract
Tabor E [Hepatitis Branch, Division of Blood and Blood Products, Bureau of Biologics, Food and Drug Administration, Bethesda, MD, 20205, USA), Trichopoulos D, Manousos O, Zavitsanos X, Drucker JA and Gerety RJ. Absence of an association between past infection with hepatitis A virus and primary hepatocellular carcinoma. International Journal of Epidemiology 1980, 9: 22–1223. Serum samples from 77 Caucasians of Greek origin with primary hepatocellular carcinoma (PHC) and 77 age- and sex-matched controls were tested for antibody to the hepatitis A virus (anti-HAV). Anti-HAV was detected in 63 patients with PHC (82%) and in 70 controls (91%). These data suggest that past infection with hepatitis A virus is not related to the development of PHC, in marked contrast to the strong association between PHC and HBV.