Synergistic Toxicity of Endotoxin with Pactamycin or Sparsomycin
- 1 August 1968
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 128 (4) , 1075-1080
- https://doi.org/10.3181/00379727-128-33197
Abstract
Summary Sublethal doses of the antitumor antibiotics, sparsomycin and pactamycin, act synergistically with bacterial endotoxin to produce ocular hemorrhage and even death of the treated BALB/sy mice. Another antitumor antibiotic, psicofuranine, in combination with endotoxin, does not result in enhanced toxicity for mice. Mice made immune to endotoxin are protected from the synergistic toxicity of endotoxin with sparsomycin.Keywords
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