A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe
- 1 April 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 332 (6164) , 509-514
- https://doi.org/10.1038/332509a0
Abstract
In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation.Keywords
This publication has 39 references indexed in Scilit:
- Cloning of the Schizosaccharomyces pombe mei3 gene essential for the initiation of meiosisMolecular Genetics and Genomics, 1985
- Mutants of the fission yeast Schizosaccharomyces pombe which alter the shift between cell proliferation and sporulationMolecular Genetics and Genomics, 1985
- Mutants of Schizosaccharomyces pombe which sporulate in the haploid stateMolecular Genetics and Genomics, 1985
- Two tightly linked silent cassettes in the mating-type region of Schizosaccharomyces pombeCurrent Genetics, 1984
- Cell type switching by DNA transposition in fission yeastNature, 1983
- Molecular rearrangement of mating-type genes in fission yeastNature, 1982
- High-frequency transformation of the fission yeast Schizosaccharomyces pombeNature, 1981
- Commitment to meiosis in fission yeastMolecular Genetics and Genomics, 1973
- Physiological aspects of conjugation in fission yeastPlanta, 1971
- Genes involved in meiosis and sporulation of a yeastMolecular Genetics and Genomics, 1968